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Safety-centric “time-cost trade-off” theory and methodology for planning industrial construction

Description

Presents results of a research project to create a cost-effective computing method to enable Time-Cost Trade-off (TCT) optimization analysis on construction projects of practical size and... More ≫

Description

Presents results of a research project to create a cost-effective computing method to enable Time-Cost Trade-off (TCT) optimization analysis on construction projects of practical size and complexity reflecting those in the real world. The researchers aim was to work toward formalizing guidelines for TCT optimization that would consider safety and time and cost constraints related to the expedition of construction projects. It is postulated that having guidelines and analysis tools such as these may decrease hazardous situations and safety risks that have been associated with expedition of construction project schedules.

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Photodynamic therapy for the treatment of Barrett’s esophagus : a systematic review and economic evaluation

Description

Barrett's esophagus is a benign condition, usually caused by long-term gastroesophageal reflux disease. In some individuals the abnormal Barrett's tissue develops precancerous cells. Barrett's... More ≫

Description

Barrett's esophagus is a benign condition, usually caused by long-term gastroesophageal reflux disease. In some individuals the abnormal Barrett's tissue develops precancerous cells. Barrett's esophagus with high grade dysplasia is associated with a higher risk of developing one type of esophageal cancer. Interventions to remove the dysplastic tissue are intended to reduce this risk. Photodynamic therapy is one of several less invasive, endoscopic treatment options for Barrett’s esophagus that offer an alternative to surgical removal of the esophagus. This review assesses the evidence on the safety and effectiveness of photodynamic therapy for the treatment of Barrett's esophagus with high grade dysplasia in comparison to esophagectomy and other endoscopic treatments for this condition. It also examines the social and economic considerations for the provision of PDT in comparison to alternate treatments.

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