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Corneal crosslinking for Keratoconus and other corneal thinning disorders

Description

Corneal thinning disorders are rare progressive disorders that can either be caused by a primary disease process (keratoconus) or may be secondary to another process; such as post... More ≫

Description

Corneal thinning disorders are rare progressive disorders that can either be caused by a primary disease process (keratoconus) or may be secondary to another process; such as post laser-in-situ-keratomileusis (LASIK) induced keratectasia (KE). It has been estimated that the most common corneal thinning disorder, keratoconus (KC), affects 1 in every 2000 people globally. Corneal crosslinking using riboflavin and ultraviolet-A radiation (CXL) is an emerging technology which may be used for managing corneal thinning disorders. The purpose of this review is to determine the safety, clinical efficacy, social impact and economic value of CXL for the management of corneal thinning disorders.

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A health technology assessment of transient elastography in liver disease

Description

Liver disease affects over two million Canadians. Liver biopsy is the current standard of care for diagnosing, staging and monitoring liver disease. It is an invasive procedure associated with a... More ≫

Description

Liver disease affects over two million Canadians. Liver biopsy is the current standard of care for diagnosing, staging and monitoring liver disease. It is an invasive procedure associated with a number of risks including bleeding, hospitalization and death. Transient elastography (TE) is an alternative, non-invasive, method of staging and monitoring liver. The intent of this report is to use current literature to determine the safety, effectiveness, social considerations and cost-effectiveness of TE for the diagnosis, staging and monitoring of liver damage associated with various liver diseases and complications due to liver transplant. The report also reviews the use of TE in paediatric patients, the use of acoustic radiation force imaging, and non-liver applications of TE.

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